麻豆国产AV

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Dongwen Lyu

Assistant Professor

Dongwen Lyu

Assistant Professor

Academic Appointment(s)

Medical College of Georgia
Department of Cellular Biology and Anatomy

Administration
Department of The Graduate School

  • DLYU@augusta.edu
  • (706) 721-8268
  • 1410 Laney-Walker Blvd, CN-3130, 麻豆国产AV, GA 30912
  • Personal Website

Education

  • Ph.D., Genetics, General Capital Normal University, 2014

  • MS, Genetics, General Capital Normal University, 2011

  • BS, Biotechnology Minzu University, 2008

Courses Taught Most Recent Academic Year

  • MOIM 9210

    Invest of a Problem

  • MOIM 8030

    Biological Signaling

  • BIOM 8230

    Biology of Proteins in Disease

  • MOIM 9040

    MOIM Journal Club

Teaching Interests

I am dedicated to teaching molecular biology and drug discovery with an emphasis on translational innovation.

Scholarship

Selected Recent Publications

  • Development of polyHis-targeting PROTAC degraders, 2026
    Journal Article, Academic Journal
  • Single-Assay characterization of Ternary Complex assembly and activity in targeted protein degradation, 2025
    Journal Article, Academic Journal
  • Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader, 2025
    Journal Article, Academic Journal
  • Discovery of BCL-xL and BCL-w dual degrader: exploration of a new linker tethering position of ABT-263, 2025
    Journal Article, Academic Journal
  • An unbiased proteomic platform for activity-based arginylation profiling. , 2025
    Journal Article, Academic Journal

Research Interests

My research focuses on targeted protein degradation and chemical biology approaches to modulate disease-associated proteins in cancer and aging. We develop innovative small-molecule degraders鈥攊ncluding PROTACs, molecular glues, and next-generation platforms鈥攁nd dissect mechanisms regulating protein folding, arginylation, alternative splicing, and protein quality control.

Department Service

  • GCC Research Faculty Recruitment Committee 2025 - Present

    Role: Committee Member

College Service

  • 11/15/25 IGP Review 2025 - 2026

    Role: Committee Member

Professional Service

  • NIH Director's Pioneer 2025 - Present

    Role: Committee Member

  • NIH Study Section 2025 - Present

    Role: Committee Member

  • NIH Study Section 2025 - Present

    Role: Committee Member

  • Angew. Chem. Int. Ed 2024 - Present

    Role: Reviewer

  • Drug Discovery Today 2024 - Present

    Role: Reviewer